Controlled release of methylene blue from layer-by-layer assembled chitosan/polyacrylic acid

Koç F. E.

International Journal of Polymeric Materials and Polymeric Biomaterials, vol.69, no.4, pp.258-262, 2019 (SCI-Expanded)


The electrostatic layer-by-layer (LbL) assembled multilayer films were widely used in the biomed-ical technology such as drug delivery. In this work, loading capabilities and release behavior of themultilayer films chitosan (Cts) and poly(acrylic acid) (PAA) were studied. The multilayer films wereassembled by LbL technique through alternating deposition of Cts and PAA on glass slides, usingmethylene blue (MB) as a model drug. All the results showed that the LBL film’s loading andrelease efficiency greatly controllable by pH and ionic strength of the solution. It suggested thatthe Cts/PAA LBL film had potential applications in drug delivery and controlled release studies.