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Lasers in Medical Science, vol.27, no.1, pp.219-222, 2012 (SCI-Expanded)
The aim of this study was to examine the cytomorphological changes occurring in the buccal mucosa in patients treated with low-level 1, 064-nm laser radiation. Seventeen individuals (12 males, five females) 18-24 years of age were included in the study. Low-level 1, 064-nm laser radiation was applied to the right buccal mucosa near the premolar region; this therapy was repeated for 10 days. Buccal epithelial cells were collected from the right and left premolar regions of the individuals with a brush before and after therapy. The specimens collected from the left side were measured cytomorphometrically and used for the control group. Student's t test was used for statistical comparison of the values of the buccal epithelial cells collected from individuals; a p value<0.05 was considered statistically significant. None of the patients showed any adverse reactions to the low-level 1, 064-nm laser radiation therapy during application. There was no cytogenetic damage to the therapied or non-therapied regions in the buccal mucosa cells, as determined cytomorphologically. The results suggest that low-level 1, 064-nm laser radiation therapy has no genotoxic potential. Within the limitations of this study, it can be concluded that low-level 1, 064-nm laser radiation therapy may be used safely in dental treatments. © 2011 Springer-Verlag London Ltd.