Ultrasound-assisted rapid synthesis of β-aminoketones with direct-type catalytic Mannich reaction using bismuth(III) triflate in aqueous media at room temperature
Chemical Papers, cilt.66, sa.1, ss.61-66, 2012 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 66 Sayı: 1
- Basım Tarihi: 2012
- Doi Numarası: 10.2478/s11696-011-0097-z
- Dergi Adı: Chemical Papers
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.61-66
- Anahtar Kelimeler: sonochemistry, beta-aminoketones, direct-type Mannich reaction, bismuth(III) triflate, green innovation
- İstanbul Gelişim Üniversitesi Adresli: Hayır
Özet
An innovative, powerful, efficient and relatively rapid method was developed to synthesise various β-aminoketone derivatives from cyclohexanone, substituted aromatic amines and aromatic or hetero-aromatic aldehydes via ultrasound-assisted direct-type catalytic Mannich reaction using bismuth(III) triflate in water. Good yields of the desired β-aminoketones were obtained at room temperature by ultrasound-assisted reaction within 1-2 h. The major advantages of the proposed method are undemanding conditions, easy operation, low toxicity, shorter reaction time, anti selectivity and higher yields in comparison with conventional methods. © 2011 Institute of Chemistry, Slovak Academy of Sciences.