Ultrasound-assisted rapid synthesis of β-aminoketones with direct-type catalytic Mannich reaction using bismuth(III) triflate in aqueous media at room temperature

Ozturkcan S. A., TURHAN K., TURGUT Z.

Chemical Papers, vol.66, no.1, pp.61-66, 2012 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 66 Issue: 1
  • Publication Date: 2012
  • Doi Number: 10.2478/s11696-011-0097-z
  • Journal Name: Chemical Papers
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.61-66
  • Keywords: sonochemistry, beta-aminoketones, direct-type Mannich reaction, bismuth(III) triflate, green innovation
  • Istanbul Gelisim University Affiliated: No

Abstract

An innovative, powerful, efficient and relatively rapid method was developed to synthesise various β-aminoketone derivatives from cyclohexanone, substituted aromatic amines and aromatic or hetero-aromatic aldehydes via ultrasound-assisted direct-type catalytic Mannich reaction using bismuth(III) triflate in water. Good yields of the desired β-aminoketones were obtained at room temperature by ultrasound-assisted reaction within 1-2 h. The major advantages of the proposed method are undemanding conditions, easy operation, low toxicity, shorter reaction time, anti selectivity and higher yields in comparison with conventional methods. © 2011 Institute of Chemistry, Slovak Academy of Sciences.