Akademik Veri Yönetim Sistemi
POLYMER BULLETIN, cilt.78, ss.3383-3398, 2020 (SCI-Expanded)
The aim of this study was to design genipin-cross-linked gelatin/chitosan flms and
investigate the swelling behavior of these flms and also investigate the release kinetics for methylene blue as a model drug. It was shown that the change in the gelatin
ratio did not have much efect on the swelling behavior, but the change in genipin
concentration had a signifcant efect on the swelling behavior of the flms. The
infuence of pH was investigated on the release profles of Methylene Blue. When
the difusion exponent value of “n” was calculated, it was observed that the difusion type in an acidic environment (pH 1.5) changed from anomalous to less Fickian due to the increase in genipin ratio. In basic conditions (pH 8.0), completely
anomalous difusion behavior was observed. As a result of the ninhydrin test, it was
revealed that the cross-linking ratio reached up to 65% when 1.5% genipin was used.
In the methylene blue model drug release studies, a very controllable release was
observed, complying with the zero-order kinetic model at low pH (pH 1.5), except
for the 1.5% genipin ratio. At high pH (pH 8.0), only 4.1 percent of the model drug
was released. It was also observed that a zero-order kinetic model was seen for all
genipin ratios. “K0,” the kinetic rate constant of model drug release, was calculated
an average 0.025 mg.min−1 at pH 1.5 and 0.001 mg.min−1 at pH 8.0, respectively.
These values show that release rate at pH 8.0 was signifcantly lower than at pH 1.5.