Synthesis and characterizations of new 1,3-oxazine derivatives

Ozturkcan S. A., TURHAN K., TURGUT Z.

Journal of the Chemical Society of Pakistan, vol.33, no.6, pp.939-944, 2011 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 6
  • Publication Date: 2011
  • Journal Name: Journal of the Chemical Society of Pakistan
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.939-944
  • Istanbul Gelisim University Affiliated: No

Abstract

In this study, Betti's classical procedure, a Mannich-type aminoalkylation reaction of 2- naphthol with various aldehydes was applied in the presence of ammonia and then 1,3- disubstituted-2,3-dihydro-1H-naphtoxazines were synthesized. The structures of the obtained new compounds have been clarified by spectroscopic methods and confirmed with elemental analysis results. From the synthesized compounds, 1,3-Di(2-naphthyl)-2,3-dihydro-1H-naphto[1,2-e][1,3] oxazine was investigation of the effects of solvent and concentration with UV-Visible Spectrophotometer. Additionally, this compound was analyzed the mutagenic and anti-mutagenic properties.