Akademik Veri Yönetim Sistemi
Turkish Journal of Nature and Science, cilt.11, sa.3, ss.69-78, 2022 (Hakemli Dergi)
Obesity, a chronic inflammatory disease, needs to be understood with a more
multidisciplinary perspective based on metabolic functioning. The rapid increase in the incidence
and prevalence of the disease in recent years has caused it to become a global health problem.
CYP1A1 is a key enzyme in the metabolization of several exogenous and endogenous substrates
including polyunsaturated fatty acids. CYP1B1 plays a regulatory role in metabolic pathways, such
as the metabolism of steroid hormones and fatty acids. Therefore, the purpose of our study is to
reveal the role of cytochrome p450 (CYP1A1 and CYP1B1) isozymes in obese patients. In addition,
this is the first study to examine the effects of CYP1A1 and CYP1B1 in obese patients concerning
various hormones, lipids, and also diabetic and whole blood parameters. Patients with obesity who
underwent bariatric surgery were included in our study and the expression of CYP1A1 and CYP1B1
in surgery tissues was determined by immunohistochemistry. CYP1A1 was weakly expressed in
33.3%, moderately in 32.5%, and strongly in 21.4% of tissues. Weak CYP1B1 expression was
observed only in 28.6% of the tissues while moderate or strong expression was not observed in any
of the tissues. No statistically significant differences were found between expression levels of
CYP1A1 and CYP1B1 isozymes in obese patients and demographic characteristics
(p>0.05).Correlation analyses were also performed between the expression levels and the clinical
data of the patients. There was a significant correlation between CYP1A1 expression and
hemoglobin levels (p<0.05). A significant correlation was found between CYP1B1 expression and
insulin as well as HDL levels (p<0.05). These detoxification enzymes could be considered one of
the key targets in obesity. However, higher expressions should be elucidated with other studies,
especially in the molecular pathway. Moreover, new approaches are needed to evaluate
susceptibility of the disease and obtain effective treatments.