When it comes to virtual currencies, the first concept that comes to mind recently is cryptocurrencies. Cryptocurrencies, which are seen as investment instruments, have started to be used as payment methods by many brands in the global market. The research is based disclosing on the intention of consumers in Turkey to use cryptocurrencies for online shopping. The purpose of this study is to explore the effects of consumers’ perceptions of the ease of use, risk and trust factors of cryptocurrencies on their perceived benefit and intention to use cryptocurrencies online within the framework of the Technology Acceptance Model (TAM). For this aim, it was discovered that perceived ease of use and trust have a significant positive effect on perceived benefit, while perceived risk has a significant negative effect, based on the analysis of data obtained from 391 consumers via the online survey technique. Perceived ease of use, trust and benefit also positively affect the intention to use cryptocurrency in online shopping. It is concluded that the perceived risk factor does not affect the intention to use cryptocurrency in online shopping. These findings provide significant theoretical and practical contributions to the fields of cryptocurrency and electronic commerce.