Efficacy of transcranial Direct Current Stimulation (tDCS) combined with intensive speech therapy for language production in monozygotic twins with corpus callosum dysgenesis (CCD): A sham-controlled single subject study

Mousavi N., Nitsche M. A., Jahan A., Nazari M. A., Hassanpour H.

Neurocase, vol.28, no.2, pp.218-225, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 2
  • Publication Date: 2022
  • Doi Number: 10.1080/13554794.2022.2071626
  • Journal Name: Neurocase
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, CINAHL, EMBASE, Linguistics & Language Behavior Abstracts, MEDLINE, Psycinfo
  • Page Numbers: pp.218-225
  • Keywords: corpus callosum dysgenesis (CCD), language learning, noninvasive brain stimulation, rehabilitation, Transcranial Direct Current Stimulation (tDCS)
  • Istanbul Gelisim University Affiliated: No

Abstract

© 2022 Informa UK Limited, trading as Taylor & Francis Group.The purpose of this single subject study was to investigate whether transcranial direct current stimulation (tDCS) applied to both hemispheres combined with speech therapy can improve language learning in a pair of 5-year-old twins with corpus callosum dysgenesis (CCD). The treatment protocol included anodal tDCS with simultaneous speech therapy in one of the participants (T.D.), and sham-tDCS with the same montage, and stimulation regime concomitant with speech therapy for the other twin (A.D.). Our findings show that T.D. improved in language production when treated with speech therapy in combination with tDCS. A.D. showed evidence for a relatively minor behavioral benefit from speech therapy.