Nurses, who have an important place in the provision of health services, face various problems while caring and applying to patients. This research was conducted to reveal the relationship between nurses' personality traits and their problem-solving skills. 228 nurses living in Istanbul, Turkey participated in the study. The collected data were analyzed with statistical analysis programs used in social sciences and as a result of the analysis, a weak positive correlation was found between Extrovert sympathetic balanced and trusting in problem solving, believing in problem solving, finding creative solutions in solving problems, biased solution approach and self upload problem. Extrovert sympathetic balanced and thoughtless approach negatively correlated very weakly. There is no relationship between extrovert sympathetic balanced and immediate decision-making approach and solving problems thoughtlessly. There was a moderate positive correlation between anxious traditional and trusting in problem solving, believing in problem solving, finding creative solutions in solving problems, biased solution approach and self upload problem. There is a very weak relationship between the anxious traditional and solving problems thoughtlessly. There is no relationship between anxious traditional and thoughtless approach and self upload problem. There is a weak positive correlation between innovative critical and trusting in problem solving, believing in problem solving, finding creative solutions in solving problems and biased solution approach. There is a weak relationship between innovative critical and self upload problem. There is no relationship between innovative critical and solving problems thoughtlessly, self upload problem and thoughtless approach