The effect of systemically administrated zoledronic acid on the osseointegration of dental implants

Ayan M., Dolanmaz D., Mihmanli A., Ayan A., Kürkçü M.

Oral Diseases, cilt.18, sa.8, ss.802-808, 2012 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 8
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1111/j.1601-0825.2012.01948.x
  • Dergi Adı: Oral Diseases
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.802-808
  • Anahtar Kelimeler: Dental implant, Non-decalcified histology, Osseointegration, Zoledronic acid
  • İstanbul Gelişim Üniversitesi Adresli: Hayır

Özet

Objective: The aim of conducting this study was to evaluate the effect of zoledronic acid (ZA) on the new bone formation (NBF) after the insertion of a titanium dental implant, which is very popular treatment in dentistry. Study Design: Twelve New Zealand white rabbits were used in this study. The rabbits were divided in two groups. ZA was systemically administered to the study group. Titanium implants were placed to the left and right tibias of the rabbits. Results: The data from the ZA group revealed a statistically significant increase in the bone mineral content and the bone mineral density. A non-decalcified histomorphometric examination conducted on the study group revealed a significant increase of NBF and bone-implant contact (BIC) at 2 and 4weeks. Conclusion: A single dose of systemic ZA administration increases the rate of NBF and augments the quality of the bone. © 2012 John Wiley & Sons A/S.