Akademik Veri Yönetim Sistemi
9th INTERNATIONAL ERCIYES CONFERENCE ON SCIENTIFIC RESEARCH, Kayseri, Türkiye, 17 - 18 Temmuz 2023, ss.52-63
Skin Cancer is triggered by oxidative stress caused by free radicals, which are formed by the
interaction of various genetic and environmental factors (such as exposure to ultraviolet (UV)
rays, smoking, genetic predisposition and immune system problems). Glutathione Stransferases (GSTs) are a family of detoxifying enzymes that protect the cell against chemical
carcinogens, toxic chemicals and reactive oxygen species. GST enzymes help reduce DNA
damage by neutralizing harmful compounds caused by free radicals. Thus, adequate levels of GST enzymes play an important role in preventing skin cancer and protecting cells from
damage. GST pi (GSTP) is an important member of this enzyme system. In this study, we aimed
to examine the expression of GSTP isozyme in 62 skin tumors and normal tissues. GSTP
expression levels of tumor and normal tissues were evaluated by immunohistochemical method
and compared with Mann Whitney-U test. Relationships between clinical and demographic data
and expression levels were evaluated with Mann Whitney-U and Kruskal Wallis tests.
Correlation analyzes were performed using the Spearman rank correlation test. Although GSTP
expression was higher in tumor tissues than in normal tissues, no significant difference was
found between groups in terms of GSTP expression (p>0.05). A statistically significant and
positive correlation was found between GSTP expressions of tumor and normal tissues
(p<0.001). A positive and significant correlation was also observed between the age of the
patients and the tumor size (p=0.040; p<0.05). It was observed that the expression level in
normal and tumor tissues from male patients was higher than in female patients. Moderately
differentiated tumors showed higher GSTP expression than well-differentiated tumors. It was
observed that the mean GSTP expression of squamous cell carcinoma tissues was higher than
basal cell carcinomas. When evaluated according to tumor stage and size, the highest expression
was found in tissues with T2 stage and 2-4 cm in size. In conclusion, the high expression of
GSTP in skin tumor tissues indicates that these parameters may have an important role in the
pathogenesis and progression of the disease. The effectiveness of GST enzymes in both cancer
prevention and treatment helps protect cells by combating oxidative stress.