Triflates promoted one-pot synthesis of functionalized unsymmetrical new dihydro-1H-indeno[1,2-B]pyridines through Hantzsch reaction under ultrasonic irradiation


TURHAN K., Ozturkcan S. A., TURGUT Z.

Journal of the Chemical Society of Pakistan, cilt.34, sa.1, ss.94-101, 2012 (Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 1
  • Basım Tarihi: 2012
  • Dergi Adı: Journal of the Chemical Society of Pakistan
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.94-101
  • Anahtar Kelimeler: Indenopyridine, Multi-component Reactions, Ultrasound, Hantzsch Reaction, Triflate
  • İstanbul Gelişim Üniversitesi Adresli: Hayır

Özet

Yb(OTf) 3 and Sc(OTf) 3 catalyzed efficient Hantzsch reaction via four-component coupling reactions of aldehydes, diketone, ethylacetoacetate and ammonium acetate at ambient temperature and medium was described as the preparation of pyridine derivatives. The process presented here is operationally simple, environmentally benign and has excellent yield. Furthermore, the catalyst can be recovered conveniently and reused efficiently. All the same, the condensation of aldehydes, ethyl acetoacetate and ammonium acetate result dihydroindenopyridines in 87-98% yields under ultrasound irradiation with catalyst at room temperature. Compared to conventional methods, the main advantages of the present procedure are milder conditions, shorter reaction time and higher yields.