Development of New Antiherpetic Drugs Based on Plant Compounds
Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and their Components, Elsevier, ss.245-259, 2013
- Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
- Basım Tarihi: 2013
- Doi Numarası: 10.1016/b978-0-12-398539-2.00017-3
- Yayınevi: Elsevier
- Sayfa Sayıları: ss.245-259
- Anahtar Kelimeler: Antiherpetic, Drug, Herpes, Plant, Virus
- İstanbul Gelişim Üniversitesi Adresli: Evet
Özet
Herpes simplex virus (HSV) infections comprise one of the most important health problems worldwide. HSV-1 and HSV-2 that are the types most frequently seen in disease, manifested by sores and blisters on the mouth, tongue, skin, and genitals of infected individuals. Moreover, herpetic infections can reach life-threatening levels; for instance, HSV-2 prevalence has increased greatly in human immunodeficiency virus-positive patients. This indicates that the herpetic infection could be a major cause of morbidity in immunosuppressed patients. Unfortunately, resistance against antiherpetic drugs has recently been reported. Therefore there is an immediate need to search for new antiviral agents in order to cope with HSV infections. Recently, it has been demonstrated that traditional medicinal plants have strong antiviral activity and some are already being used in the treatment of viral infections, including herpes simplex infections. Accordingly, this chapter aims to present published information on various herbal compounds, investigate the antiherpetic effectiveness of these compounds, and determine the potential of plants as herpetic treatments in the future. © 2013 Elsevier Inc. All rights reserved.