The 5S System, which is the front step of lean production, is a systematic approach that provides the contribution of all workers to the maintenance and cleaning regime of the company and includes classification, regulation, cleaning, standardization, and discipline steps. With the 6S (5S+Safety) System created with the safety step added to this system, the zero-accident principle in occupational health and safety is aimed by ensuring an increase in quality and productivity in a clean and orderly working environment. In this study, the 6S (5S+Safety) System, which is used to control both simple and smallest details by providing order and discipline in businesses, has been examined in detail. A sample assembly line was selected as a pilot section for the activities implemented in an automotive supply industry parts manufacturing company and included in the research. Weekly evaluations of the studies carried out for 20 weeks were made and the weekly development of the 6S (5S+Safety) System, which was implemented by creating graphics because of the scoring system created using checklists, was followed. As a result of weekly improvement studies, it has been observed that the quality of sustainable occupational safety performance has increased continuously, and the target level has been reached for the company. It is aimed that this study will be a guide showing how the 6S (5S+Safety) System is applied to company managers, quality unit employees, occupational safety experts and researchers working in this field.