© TÜBI˙TAK.In this paper, by considering a Frenet curve lying on an oriented hypersurface, we extend the Darboux frame field into Euclidean 4-space E4 . Depending on the linear independency of the curvature vector with the hypersurface's normal, we obtain two cases for this extension. For each case, we obtain some geometrical meanings of new invariants along the curve on the hypersurface. We also give the relationships between the Frenet frame curvatures and Darboux frame curvatures in E4 . Finally, we compute the expressions of the new invariants of a Frenet curve lying on an implicit hypersurface.