The Association of ACTN3 Rs1815739 Polymorphism with Various Malocclusion Phenotype


Izaddin Alalim H. N., Eken B. F., Ulucan K., Özdemir F.

Turkish Journal of Orthodontics, vol.35, no.2, pp.127-132, 2022 (ESCI)

  • Publication Type: Article / Article
  • Volume: 35 Issue: 2
  • Publication Date: 2022
  • Doi Number: 10.5152/turkjorthod.2022.21171
  • Journal Name: Turkish Journal of Orthodontics
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.127-132
  • Istanbul Gelisim University Affiliated: Yes

Abstract

Objective: A functional polymorphism on the 16th exon of the alpha-actinin-3 gene has an effect on the protein structure and cellular signaling and therefore on muscle contraction. In this study, we aimed to analyze the alpha-actinin-3 rs1815739 polymorphism in 3-dimensional malocclusions and different craniofacial skeletal patterns.

Methods: Forty-nine volunteering subjects enrolled for the study. Genotyping of alpha-actinin-3 rs1815739 polymorphism was per- formed using real-time polymerase chain reaction. Pre-orthodontic cephalometric radiographs were traced using NemoTech ceph- alometric tracing software. IBM SPSS Statistics for Windows was utilized to carry out statistical analysis. P < .05 was considered to be statistically significant.

Results: The respective numbers and the percentages of alpha-actinin-3 rs1815739 polymorphisms for RR, RX, and XX genotypes were 39 (79.6%), 4 (8.2%), and 6 (12.2%), respectively. Twenty-one patients had low angle vertical patterns and 17 patients had Class I and the same number of the patients had Class III facial patterns. But none of these had statistically significant difference in terms of alpha-actinin-3 rs1815739 polymorphism and in vertical or sagittal facial patterns, and mandibular incisor inclination. When we examined the maxillary anteroposterior position, we found a significant difference between rs1815739 polymorphisms (P < .05). Also, we detected a significant difference between rs1815739 polymorphism and maxillary incisor inclination (P < .05).