Akademik Veri Yönetim Sistemi
9. International Congress of Molecular Medicine, İstanbul, Türkiye, 18 - 20 Aralık 2023, ss.1-2
Dry eye disease, which occurs due to dysfunction of the lacrimal gland, is one of the most common eye diseases that causes corneal epithelial damage and results in significant vision loss and reduced quality of life. Maintaining a homeostatic microenvironment is crucial for a healthy ocular surface. Valproic acid/valproate is a broad-spectrum anti-epileptic drug. Although this drug has many side effects, its effects on the extraorbital lacrimal gland are unknown. Moringa oleifera (M. oleifera) is a plant widely used as food and folk medicine in Africa and Asia. It is stated that M. oleifera protects eye health with the high concentration of vitamin A. The lack of sufficient curative treatments for dry eye disease directs researchers to find more permanent and sustainable treatment options. In this study, the effects of sodium valproate and M. oleifera on the extraorbital lacrimal gland of rats were examined. The lipid peroxidation and total oxidant levels in groups, defined as control, control + moringa extract, sodium valproate and sodium valproate + moringa extract, were determined. Valproate induced oxidative stress by significantly increasing the total oxidant and lipid peroxidation levels in the rat extraorbital lacrimal gland. M. oleifera extract exhibited protective properties, reversing these valproate-induced changes due to its antioxidant and therapeutic attributes. This research suggests that moringa extract might serve as an alternative treatment approach for individuals using sodium valproate and experiencing extraorbital lacrimal gland issues.