Structural, mechanical and biomedical impacts of defects in Cu/Mg Co-doped ZnO nanoparticles

ŞENTÜRK K.

Micro and Nanostructures, cilt.208, 2025 (SCI-Expanded, Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 208
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1016/j.micrna.2025.208362
  • Dergi Adı: Micro and Nanostructures
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Cu/Mg co-doping, Defects, Hemolysis, Microstructure, Nanoparticle, Williamson-Hall method
  • İstanbul Gelişim Üniversitesi Adresli: Evet

Özet

Zn0.99-xCu0.01MgxO (x = 0–0.05) nanoparticles were synthesized by a sol–gel route and examined to relate doping-induced lattice defects to biocompatibility for prospective biomedical use. X-ray diffraction confirmed single-phase wurtzite with no secondary phases, while Williamson–Hall models provided crystallite size and lattice microstrain/stress, separating strain from size effects. Photoluminescence (UV–visible) showed an Mg-dependent defect redistribution suppression of the green band (VO) with concomitant changes in Zni, VZn, and Oi centers. SEM/EDS verified the expected composition and quasi-spherical agglomerated morphology. Hemolysis assays on human erythrocytes revealed a monotonic decrease in lysis with increasing Mg; samples with x ≥ 0.04 were non-hemolytic at 1.0 mg/mL (ISO <5 %). Overall, Mg-enabled defect passivation particularly VO suppression correlates with improved blood compatibility, indicating that Cu/Mg co-doping is a practical lever to tailor ZnO nanoparticles for blood-contacting coatings, sensors, and implant interfaces.