Template synthesis, characterization, and antimicrobial activity of a new lead (II) Schiff base complex

Beynek N., Tan N., Beynek H.

Main Group Metal Chemistry, vol.38, no.5-6, pp.145-150, 2015 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 5-6
  • Publication Date: 2015
  • Doi Number: 10.1515/mgmc-2015-0018
  • Journal Name: Main Group Metal Chemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.145-150
  • Keywords: antimicrobial activity, lead (II), Schiff base, template reaction
  • Istanbul Gelisim University Affiliated: Yes


A novel lead (II) complex of Schiff base containing three bipyridine units was synthesized by the template reaction between a new amine compound, 6-methyl-6′-(2-aminophenoxymethyl)-2,2′-bipyridine, and 2,2′-bipyridine-6,6′-dicarboxaldehyde in the presence of a Pb(II) perchlorate ion. The new amino compound and Schiff base complex, [PbL](ClO4)2·2H2O, were characterized by using matrix-assisted laser desorption/ionization with time-of-flight mass spectroscopy, FAR FT-IR, UV/visible spectroscopy, 1H NMR, elemental analyses (CHN), and molar conductivity measurements. Then the synthesized complex was screened in vitro for its antibacterial and antifungal activities against three Gram-negative and two Gram-positive bacteria and also against Candida albicans as a fungus by the microdilution broth method as a minimal inhibitory concentration. [PbL](ClO4)2·2H2O exhibits moderate activity on Staphylococcus aureus and Listeria monocytogenes when compared with standard drug and also shows moderate antifungal activity on the fungus Candida albicans.