EFFECT OF TWEEN 80 ON THE STABILITY AND CONFORMATION OF TELOMERIC G-QUADRUPLEX DNA

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ELHATY I. A. M.

Chemistry and Chemical Technology, vol.17, no.3, pp.567-573, 2023 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 3
  • Publication Date: 2023
  • Doi Number: 10.23939/chcht17.03.567
  • Journal Name: Chemistry and Chemical Technology
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
  • Page Numbers: pp.567-573
  • Keywords: circular dichroism, conformation, quadruplex, telomere, Tween 80
  • Istanbul Gelisim University Affiliated: Yes

Abstract

G-quadruplex DNA is formed in telomer. It inhibits telomerase enzyme which is found active in more than 85 % of cancer cells. In this work, the effect of Tween 80 on telomeric G-quadruplex DNA, AGGG(TTAGGG)3 was studied using circular dichroism spectroscopic technique. The obtained results showed that using Tween 80 with telomeric quadruplex is safe up to less than 1.0 %.