EFFECT OF TWEEN 80 ON THE STABILITY AND CONFORMATION OF TELOMERIC G-QUADRUPLEX DNA

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ELHATY I. A. M.

Chemistry and Chemical Technology, cilt.17, sa.3, ss.567-573, 2023 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 3
  • Basım Tarihi: 2023
  • Doi Numarası: 10.23939/chcht17.03.567
  • Dergi Adı: Chemistry and Chemical Technology
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.567-573
  • Anahtar Kelimeler: circular dichroism, conformation, quadruplex, telomere, Tween 80
  • İstanbul Gelişim Üniversitesi Adresli: Evet

Özet

G-quadruplex DNA is formed in telomer. It inhibits telomerase enzyme which is found active in more than 85 % of cancer cells. In this work, the effect of Tween 80 on telomeric G-quadruplex DNA, AGGG(TTAGGG)3 was studied using circular dichroism spectroscopic technique. The obtained results showed that using Tween 80 with telomeric quadruplex is safe up to less than 1.0 %.