EFFECT OF TWEEN 80 ON THE STABILITY AND CONFORMATION OF TELOMERIC G-QUADRUPLEX DNA
Chemistry and Chemical Technology, cilt.17, sa.3, ss.567-573, 2023 (ESCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 17 Sayı: 3
- Basım Tarihi: 2023
- Doi Numarası: 10.23939/chcht17.03.567
- Dergi Adı: Chemistry and Chemical Technology
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
- Sayfa Sayıları: ss.567-573
- Anahtar Kelimeler: circular dichroism, conformation, quadruplex, telomere, Tween 80
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- İstanbul Gelişim Üniversitesi Adresli: Evet
Özet
G-quadruplex DNA is formed in telomer. It inhibits telomerase enzyme which is found active in more than 85 % of cancer cells. In this work, the effect of Tween 80 on telomeric G-quadruplex DNA, AGGG(TTAGGG)3 was studied using circular dichroism spectroscopic technique. The obtained results showed that using Tween 80 with telomeric quadruplex is safe up to less than 1.0 %.