EFFECT OF TWEEN 80 ON THE STABILITY AND CONFORMATION OF TELOMERIC G-QUADRUPLEX DNA
Chemistry and Chemical Technology, vol.17, no.3, pp.567-573, 2023 (ESCI, Scopus)
- Publication Type: Article / Article
- Volume: 17 Issue: 3
- Publication Date: 2023
- Doi Number: 10.23939/chcht17.03.567
- Journal Name: Chemistry and Chemical Technology
- Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
- Page Numbers: pp.567-573
- Keywords: circular dichroism, conformation, quadruplex, telomere, Tween 80
- Open Archive Collection: AVESIS Open Access Collection
- Istanbul Gelisim University Affiliated: Yes
Abstract
G-quadruplex DNA is formed in telomer. It inhibits telomerase enzyme which is found active in more than 85 % of cancer cells. In this work, the effect of Tween 80 on telomeric G-quadruplex DNA, AGGG(TTAGGG)3 was studied using circular dichroism spectroscopic technique. The obtained results showed that using Tween 80 with telomeric quadruplex is safe up to less than 1.0 %.